1980.09-1984.07?四川大學化學系，獲理學學士學位

1984.09-1987.07?蘭州大學化學系有機合成專業，獲理學碩士學位

1987.07-1990.09?中國科學院成都生物研究所，從事天然藥物化學研究，助研（1989.07）

1990.09-1993.09?波恩大學數學——自然科學學院藥物研究所，獲理學博士學位。

1993.09-1994.12?波恩大學數學——自然科學學院藥物研究所，從事抗腫瘤活性天然產物的研究

1995.01-1996.11?北京大學化學與分子工程學院有機化學研究所，博士后,從事天然有機化學的研究?????????????????

1996.11-? 中國科學院成都生物研究所從事天然藥物化學的研究，研究員（1997）、博士生導師（1999）

1999?? 入選“百千萬人才工程”

2001?? 中國科學院青年科學家獎

2003?? 入選“四川省學術技術帶頭人”

2004?? 第七屆四川省青年科技獎

2006?? 中國科學院優秀教師

2006?? 四川省優秀回國人員

2007?? 國務院政府特殊津貼

2013?? 四川省人民政府，四川省科學技術進步獎，一等獎（2/9）

2022.1-2026.12?國家自然科學基金重大項目課題，瀕危藥材獨特療效物質研究——瀕危藥材復雜體系中獨特療效物質的精準表征

2019.01-2022.12?國家自然科學基金面上項目，

毛殼霉中新穎多聚吲哚生物堿的結構與活性

2019.01-2021.12?國家自然科學基金國際（地區）合作與交流項目，（NSFC-TRF項目)，基于天然產物的老年性疾病候選藥物研究

2018.1-2020.12?國家重大新藥創制(科技部)課題，具重要生物活性的天然小分子化合物的高效鑒定

2016.01-2018.12?國家自然科學基金國際（地區）合作與交流項目，（NSFC-TRF項目)，治療老年性疾病的天然產物藥物發現研究

2014.01-2017.12?國家自然科學基金面上項目，苯并呋喃：基于分子內脫羧、C-O鍵形成的合成與芳香化酶抑制活性

2013.01-2015.12?國家自然科學基金重大研究計劃集成項目課題，基于小分子探針的細胞命運決定的分子機制研究——調控JAK-STAT信號過程的天然產物

2012.01-2015.12?國家自然科學基金面上項目，淫羊藿苷及類似物的合成與構效關系研究

2010.01-2013.12?國家自然科學基金重點項目，天然產物對雌激素合成和代謝調控機制的研究

2009.01-2013.12?國家重點基礎研究發展計劃（973計劃）課題, 確有療效的有毒中藥科學應用關鍵問題的基礎研究——有毒中藥毒效物質基礎研究

1. Jing Wang, Xueqing Qian, Tao Yang, Dabin Hou, Guolin Zhang,* Guoyou Li，* Chaetomadramines A–E, a Class of Siderophores with Potent Neuroprotective Activity from the Fungus Chaetomium madrasense cib-1, Fitoterapia, 2023, 164: 105351.?

2. Daijing Wei, Yun Yang, Ruiying Xi, Yunqing He, Ighodaro Igbe, Fei Wang, Guolin Zhang,* Yinggang Luo, * Hunteriasines A – D, Tryptamine-derived Alkaloids from Hunteria umbellate, Phytochemistry, 2023, 213: 113572..

3. Xueqing Qian,^# Guobo Xu,^# Lingyan Liu, Tao Yang, Guolin Zhang,* Guoyou Li,* Chaetonigrisins A–L, A Group of 3-Indole-1,2-propanediol Derived Alkaloids from Chaetomium nigricolor YT-2, Bioorganic Chemistry, 2022, 130:106201.

4. Ting Peng,^# Yujiao He,^# Tao Wang,^# Jialing Yu,^# Xiaofang Ma,^# Zongyuan Zhou, Yuwen Sheng, Lingyu Li, Huipan Peng, Sheng Li, Jiawei Zou, Yi Yuan, Yongyun Zhao, Hailong Shi, Fu Li, Wanli Liu, Kaifeng Hu,* Xiaoxia Lu,* Guolin Zhang,* Fei Wang,* Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP?Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis, Journal of Medicinal Chenistry, 2022, 65: 11010?11033. ?

5. Xuejian Zhang,^# Yu Cao,^# Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang,* Yinggang Luo,* Antifibrotic Pyridine-containing Monoterpene Alkaloids from Caryopteris glutinosa, Phytochemistry, 2022,203:113378

6. Yuwen Sheng,^# Yuwen Chen,^# Zhongqiu Zeng, Wenbi Wu, Jing Wang, Yuling Ma, Yuan Lin, Jichao Zhang, Yulan Huang, Wenhua Li, Qiyu Zhu, Xiao Wei, Suiyan Li, Wisanee Wisanwattana, Fu Li, Wanli Liu, Apichart Suksamrarn, Guolin Zhang,* Wei Jiao, * Fei Wang,* Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming，Journal of Medicinal Chemistry,?2022, 65: 460?484.

7. Naijie Fu, Ruiying Xi, Xiaoke Shi, Runze Li, Zhonghui Zhang, Lingyu Li, Guolin Zhang,* Fei Wang,* Hexachlorophene, a Selective SHP2 Inhibitor, Suppresses Proliferation and Metastasis of KRAS-mutant NSCLC Cells by Inhibiting RAS/MEK/ERK and PI3K/AKT Signaling Pathways,Toxicology and Applied Pharmacology, 2022, 441: 115988

8. Xuejian Zhang, Guoyong Luo, Yu Cao, Dumaa Mishig, Munkhgerel Lodonjav, Dabo Pan, Xiaojun Yao, Fei Wang, Guolin Zhang,* Yinggang Luo，* ( )-Caryopterisines A and B, Dimeric Monoterpene Alkaloids with Unprecedented 6/5/5/5/6 Pentacyclic Rings Scaffold from Caryopteris glutinosa，Bioorganic Chemistry, 2021, 116: 105364.

9. Wisanee Wisanwattana,^# Kanjana Wongkrajang,^# Dongyi Cao, Xiaoke Shi, Zhonghui Zhang, Zongyuan Zhou, Fu Li, Qinggang Mei, Chun Wang, Apichart Suksamrarn, Guolin Zhang,* Fei Wang，* Inhibition of Phosphodiesterase 5 Promotes the Aromatase- Mediated Eestrogen Biosynthesis in Osteoblastic Cells by Activation of cGMP/PKG/SHP2 Pathway, Frontiers in Endocrinology, 2021, 12: Article 636784.

10. Ting Peng, Orawan Wonganan , Zhonghui Zhang , Jialing Yu , Ruiying Xi , Yu Cao , Apichart Suksamrarn , Guolin Zhang,* Fei Wang，* A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating??-TrCP E3 Ubiquitin Ligase，International Journal of Molecular Sciences, 2021, 22: 3354.

11. Wei Xiong,^# Xiaohong Wang,^# Xianyan Shen, Cuifang Hu, Xin Wang, Fei Wang, Guolin Zhang,* Chun Wang,* Synthesis of Flavonols via Pyrrolidine Catalysis: Origins of the Selectivity for Flavonol versus Aurone, Journal of Organic Chemistry, 2020, 85: 13160-13176.

12. Xuejian Zhang, Ting Peng, Xiaoke Shi, Dongmei Fang, Lin Tang, Fang Chen, Fei Wang, Guolin Zhang，* Yingguo Luo,*? Diterpenoids Caryopterisoids D - Q and Iridoid Glucoside Derivatives Caryopterisides F-H from Caryopteris glutinosa, Phytochemistry, 2020, 180: 112534